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Cystic fibrosis year in review Review Pediatr Pulmonol. Online ahead of print. David V Swetland MediFind. This past year, there were many important advances for patients with cystic fibrosis CF. The aim of this review article is not to provide a full assessment of the wide range of articles published in , but to provide a brief review of publication that may lead to changes in clinical care.

The full referenced text is available via the PubMed link. Future therapies for cystic fibrosis. Review Nat Commun. Free PMC article pubmed. We are currently witnessing transformative change for people with cystic fibrosis with the introduction of small molecule, mutation-specific drugs capable of restoring function of the defective protein, cystic fibrosis transmembrane conductance regulator CFTR. However, despite being a single gene disorder, there are multiple cystic fibrosis-causing genetic variants; mutation-specific drugs are not suitable for all genetic variants and also do not correct all the multisystem clinical manifestations of the disease.

For many, there will remain a need for improved treatments. Those patients with gene variants responsive to CFTR modulators may have found these therapies to be transformational; research is now focusing on safely reducing the burden of symptom-directed treatment.

However, modulators are not available in all parts of the globe, an issue which is further widening existing health inequalities. For patients who are not suitable for- or do not have access to- modulator drugs, alternative approaches are progressing through the trials pipeline. There will be challenges encountered in design and implementation of these trials, for which the established global CF infrastructure is a major advantage.